5/7/2023 0 Comments Mps pediatrics![]() Newborn screening in India, experience from pilot initiative (ICMR Multicenter Project). Abstract presented at 8th Asia Pacific Regional Meeting of the International Society for Neonatal Screening. Newborn screening for congenital hypothyroidism- experience from India. Preliminary report on neonatal screening for congenital hypothyroidism, congenital adrenal hyperplasia and glucose-6-phosphate dehydrogenase deficiency: a Chandigarh experience. Neonatal screening for congenital hypothyroidism using the filter paper thyroxine technique. Screening for congenital hypothyroidism: results of screening one million North American infants. 1975 86:670–4.įisher DA, Dussault JH, Foley TP Jr, et al. Preliminary report on a mass screening program for neonatal hypothyroidism. 92–8.ĭussault JH, Coulombe P, Laberge C, Letarte J, Guyda H, Khoury K. Birth Defects Original Article, Series IV 1962. Screening for inborn errors of metabolism in the newborn infant- a multiple test program. A case for clarity, consistency and helpfulness: state-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system. Swiglo BA, Murad MH, Schunemann HJ, et al. Newborn screening strategies for congenital hypothyroidism: an update. Newborn screening for congenital hypothyroidism, galactosemia and biotinidase deficiency in Uttar Pradesh, India. Gopalakrishnan V, Joshi K, Phadke SR, et al. Babies with the possibility of transient congenital hypothyroidism should be re-evaluated at age 3 y, to assess the need for lifelong therapy. Serum T4/FT4 is measured at 2 wk and TSH and T4/FT4 at 1 mo, then 2 monthly till 6 mo, 3 monthly from 6 mo-3 y and every 3–6 mo thereafter. Levothyroxine is commenced at 10 to 15 μg/kg in the neonatal period. Imaging is recommended by radionuclide scintigraphy and ultrasonography after CH is biochemically confirmed but treatment should not be delayed till scans are performed. Venous confirmatory TSH >20 mIU/L before age 2 wk and >10 mIU/L after age 2 wk, with low T4 (<10 μg/dL) or FT4 (<1.17 ng/dL) indicate primary CH and treatment initiation. ![]() ![]() Sick babies should be screened at least by 7 d of age. Preterm and low birth weight infants should undergo screening at 48–72 h postnatal age. For screen TSH > 40 mIU/L, immediate confirmatory venous T4/FT4 and TSH, and for milder elevation of screen TSH, a second screening TSH at 7 to 10 d of age, should be taken. On this screen sample, neonates with TSH > 20 mIU/L serum units (or >34 mIU/L for samples taken between 24 to 48 h of age) should be recalled for confirmation. Recommendations: Screening should be done for every newborn using cord blood, or postnatal blood, ideally at 48 to 72 h of age. The Indian Society for Pediatric and Adolescent Endocrinology has formulated locally relevant Clinical Practice Guidelines for newborn screening, diagnosis and management of primary congenital hypothyroidism (CH). ![]()
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